Massachusetts voters decisively rejected Ballot Question 4, which aimed to legalize and regulate certain natural psychedelics, such as psilocybin and mescaline, for therapeutic use under licensed supervision. The measure was defeated with 57% voting against it, despite proponents highlighting its potential benefits for mental health treatment and tax revenue generation. Opponents, including the Coalition for Safe Communities, argued that the measure, which would have permitted home cultivation, was poorly conceived and posed public safety risks. Advocates of the initiative acknowledged concerns over its home-grow provisions possibly contributing to its defeat but emphasized ongoing efforts to promote psychedelic therapy. Similar measures have seen varied success in other states, like Colorado, where a comparable initiative passed, contrasting with Massachusetts' decision. Overall, the result signifies a cautious stance on psychedelics in the state, amidst a broader national debate on their medicinal use.