The highly anticipated presidential debate between Vice President Kamala Harris and former President Donald Trump is set for September 10 at 9 p.m. EDT, hosted by ABC at the National Constitution Center in Philadelphia. This event marks the first and potentially only face-off between the two candidates, with Harris now leading the Democratic ticket after President Biden's withdrawal. Moderated by David Muir and Linsey Davis, the debate will follow strict rules, including muted microphones for candidates when not speaking. Both candidates are under pressure to perform well as they campaign in key swing states, with Trump recently recovering from an assassination attempt. Minnesota Governor Tim Walz, Harris' running mate, is also campaigning in Arizona ahead of the debate, emphasizing the significance of the upcoming election. The debate will be broadcast live on multiple platforms, including ABC News Live, Disney+, and Hulu.