Jennifer Aniston has publicly criticized Republican vice presidential nominee JD Vance for his derogatory comments about 'childless cat ladies,' which resurfaced from a 2021 interview. Vance argued that childless politicians, such as Kamala Harris and Pete Buttigieg, lack a 'direct stake' in the country's future. Aniston responded on Instagram, highlighting her own IVF struggles and condemning Vance's stance. The backlash has been widespread, with many criticizing Vance's comments as sexist and dismissive of the contributions of childless individuals. Prominent figures, including Sen. Elizabeth Warren, have also condemned Vance’s remarks, calling them 'way outside the mainstream.' Social media users have rallied in defense of Harris and others targeted by Vance, emphasizing that childlessness does not equate to a lack of commitment to the nation's future.