Mexican drug cartels like Sinaloa and CJNG are expanding their operations into the US, particularly Hawaii, flooding the islands with methamphetamines and fentanyl, targeting areas with less competition and law enforcement. The DEA has launched initiatives like 'Operation Overdrive' to combat these cartels, emphasizing community involvement in reporting suspicious activities. Cartels use various methods like smuggling drugs in passengers' luggage, mailed packages, and body carriers to reach Hawaii. The growing drug problem poses serious health risks, with substances like pink cocaine being mixed with dangerous components, leading to severe health issues and fatalities.