New research from the University of Washington indicates that COVID-19 lockdowns accelerated brain aging in teenagers, with girls experiencing a more pronounced effect. The study, published in the Proceedings of the National Academy of Sciences, found that while boys' brains aged by an average of 1.4 years, girls' brains aged by 4.2 years. This accelerated maturation, measured via cortical thinning, is linked to increased risks of neuropsychiatric and behavioral disorders. The differences may be due to the varying reliance on social interactions, with girls depending more on personal connections for emotional support. Researchers emphasized the profound impact of lockdown-induced isolation on adolescent mental health, highlighting the need for targeted interventions. The long-term consequences of these changes remain uncertain and warrant further investigation.