No. 20 SMU dominated No. 18 Pittsburgh with a decisive 48-25 victory, marking the Panthers' first loss of the season. Kevin Jennings threw for 306 yards and two touchdowns, while Brashard Smith rushed for 161 yards and scored twice, including a 71-yard touchdown run. The Mustangs took an overwhelming lead in the second quarter, scoring 24 points to lead 31-3 at halftime. Pitt struggled significantly, with quarterback Eli Holstein completing 29 of 47 passes for 248 yards, but the team could not establish an offensive rhythm, leading to multiple errors and penalties. The win keeps SMU unbeaten in the Atlantic Coast Conference, tied for first place with No. 5 Miami. Following the game, Pitt fans reacted negatively on social media, expressing disappointment in the team's performance and coaching decisions.