John Mulaney returned as host of Saturday Night Live, marking his sixth appearance, and brought humor to both his family life and personal challenges. He joked about his recent experiences as a new father to his daughter Méi June and his son Malcolm, highlighting the unequal division of parenting responsibilities. Mulaney also referenced his 2020 rehab stint during his monologue, using humor to address his past struggles with addiction. The episode featured a surprise appearance by Vice President Kamala Harris, who engaged in political satire alongside Maya Rudolph, enhancing SNL's 50th-season theme of blending comedy with current events. Mulaney's performance was complemented by musical guest Chappell Roan, rounding out a memorable night of entertainment. His remarks on his health issues, including potential hip replacement surgery, added a personal touch to his comedic routine.