The Great Smoky Cannabis Company in Cherokee, North Carolina, opened its doors to the public for recreational marijuana sales on September 7, making it the first dispensary for adult-use cannabis in the state. Customers aged 21 and older, regardless of residency, can purchase marijuana without needing a medical card, following a successful tribal referendum that garnered 70% support. The dispensary had previously allowed sales to medical cardholders and tribal members since its opening earlier this year. This move reflects the tribe's assertion of sovereignty and has sparked discussions about the implications for federal funding and state regulations, as marijuana remains illegal in North Carolina. The Eastern Band of Cherokee Indians anticipates significant revenue from these sales, potentially reaching $385 million in the first year. This historic opening not only serves local residents but also caters to tourists, promising to boost the local economy.