49ers Rule Out Key Players for Rams Game

The San Francisco 49ers have ruled out All-Pro left tackle Trent Williams and safety Malik Mustapha for their crucial matchup against the Los Angeles Rams, while edge rusher Nick Bosa and running back Isaac Guerendo are listed as questionable. Williams will miss his fourth consecutive game due to an ankle injury, a significant loss as the 49ers have struggled without him, holding a 4-6 record in his absence. Bosa, who has been sidelined for three games with hip and oblique injuries, participated in a limited walk-through on Wednesday, raising hopes for his return. Guerendo, recovering from a foot sprain, is also uncertain for the game, as the team hopes he can contribute despite his injury. Linebacker Dre Greenlaw may make his return after a long absence due to an Achilles injury, adding a potential boost to the 49ers' defense. Both teams are aware of the stakes, as this game is critical for playoff aspirations.