Louisville football will host Georgia Tech for their ACC opener after an early bye week, with the Cardinals ranked No. 19 by the AP and No. 20 in the Coaches Poll. Louisville replaced Indiana, who bought out of a series, with Jacksonville State and has dominated their first two games. Georgia Tech, standing at 3-1, has faced tougher competition, including an opening win against Florida State in Ireland. The Yellow Jackets have struggled defensively in the passing game, ranking 110th nationally, making Louisville's strong passing offense a key factor. Louisville opens as a 10.5-point favorite according to FanDuel Sportsbook. This will be the fourth meeting between the teams, with Georgia Tech leading the series 2-1.