Michigan football is facing a challenging season after a disappointing 21-7 loss to Illinois, but remains a six-point favorite against Michigan State, seeking its third consecutive victory over its rivals. Meanwhile, Nebraska is struggling after a heavy defeat to Indiana and is opening as a 25.5-point underdog against Ohio State, reflecting their tough schedule ahead. Oregon has ascended to the No. 1 spot in the AP college football poll following Texas's loss, marking the fourth team to hold the top position this season. The Ole Miss Rebels are also looking to bounce back after a bye week, facing Oklahoma, who is coming off a demoralizing loss to South Carolina. With their playoff hopes on the line, Ole Miss is favored by 18.5 points in their upcoming matchup. Overall, the college football landscape is experiencing significant shifts as teams jockey for position heading into the latter part of the season.