Two separate fatal crashes occurred on major highways in the U.S., resulting in one death in each incident. In Mississippi, an early morning collision involving an 18-wheeler on Interstate 22 left one person dead at the scene, while authorities blocked all lanes due to the overturned truck. In Oregon, a multi-vehicle crash on Highway 99 killed one person and seriously injured another; the incident involved a large truck and two passenger vehicles, with emergency responders rescuing individuals from entrapment and fire. Both highways remain closed for investigations, and officials are urging witnesses to come forward to assist in inquiries. The Mississippi incident occurred just before 2:30 a.m., while the Oregon crash was reported around 10:13 a.m. on the same day.