Research is delving into the intricate mechanisms of opioid tolerance, particularly associative opioid tolerance (AOAT), shedding light on how environmental cues influence drug response. Meanwhile, initiatives like Called2Duty in Arkansas aim to combat the opioid crisis by providing education, naloxone training, and support for veterans struggling with addiction. On a broader scale, a study in Canada suggests that a government-led educational intervention successfully encouraged long-term opioid users to reduce their dosages. However, substance use treatment facilities in the US still face significant gaps in providing effective treatments for opioid use disorder, with many not offering medications or multiple types of medications for OUD.