Single Psilocybin Dose Provides Up to 5 Years Depression Relief

Recent studies have revealed that a single dose of psilocybin, the psychoactive compound found in magic mushrooms, combined with psychological support, can provide significant and long-lasting relief from depression and anxiety. In cancer patients with major depressive disorder, clinical trials showed that one 25 mg dose of psilocybin led to sustained improvements in mental health for up to two years, with over half of patients experiencing significant symptom reductions. Additionally, follow-up research on patients with major depressive disorder found that the antidepressant effects of psilocybin could last up to five years after treatment, offering a promising alternative to traditional antidepressants that require continuous administration. These findings were presented at the Psychedelic Science 2025 conference and emphasize psilocybin's potential as a transformative mental health treatment when combined with therapy. Experts highlight that this treatment could be a breakthrough for those with life-threatening illnesses and chronic depression, as it may reset brain activity patterns linked to depressive symptoms. The Trump administration is also exploring psychedelics as potential mental health treatments, reflecting growing interest in these therapies.