A deadly new variant of the mpox virus, Clade 1b, has emerged, prompting the World Health Organization (WHO) to declare a global health emergency. The strain, which has a high mortality rate, particularly among children, has spread from the Democratic Republic of Congo (DRC) to other parts of Central and East Africa, and now Europe and Asia. European and Asian countries, including Sweden, Pakistan, and China, have reported their first cases and are increasing vigilance, implementing screening measures, and educating travelers. The United States Centers for Disease Control and Prevention (CDC) has updated its guidance and risk assessments, while the UK and India are preparing for potential outbreaks despite currently low risk levels. Rapid testing, isolation protocols, and vaccination campaigns are being emphasized as critical measures to contain the spread.