Liverpool will face Aston Villa at Anfield as they aim to maintain their lead in the Premier League, despite missing several key players due to injury, including Alisson Becker and Diogo Jota. Meanwhile, Manchester City is desperate to end a three-match losing streak when they travel to Brighton, with Pep Guardiola's side currently two points behind Liverpool in the table. City has not lost four consecutive games under Guardiola's management, making this match critical for their title defense. Brighton, having recently faced Liverpool, hopes to capitalize on City's struggles, featuring in-form striker Danny Welbeck. Both teams have confirmed their lineups, with City making two changes from their last match, bringing back Kyle Walker and Ilkay Gundogan while five players remain sidelined due to injuries. The outcomes of these matches could significantly impact the Premier League standings ahead of the international break.