Christina Applegate, 52, recently opened up about her diagnosis of multiple sclerosis (MS) during an interview on SiriusXM's 'This Life of Mine' with James Corden. She described a long struggle with unexplained symptoms, such as balance and speech issues, which she initially dismissed as dehydration or heat-related. In January 2021, as her mother was diagnosed with cancer, Applegate experienced numbness in her toes and eventually sought medical testing, leading to her MS diagnosis confirmed via an MRI that revealed multiple lesions on her brain. She recalled the emotional moment when her doctor delivered the news, stating, 'It's f--king MS,' which prompted a temporary halt in her production schedule for 'Dead to Me.' Despite her health challenges, Applegate finds comfort in reality television, which she credits as a significant coping mechanism during her journey. She expressed her desire to be more open about her condition, stating, 'This is my coming out party,' embracing her true self after years of putting on a facade.