Chiefs Edge Chargers 17-10, Improve to 4-0

In a dramatic comeback, the Kansas City Chiefs defeated the Los Angeles Chargers 17-10, with Patrick Mahomes marking his 100th regular-season start by passing for 245 yards and a touchdown. The Chiefs trailed 10-0 early, but their defense held strong, allowing the team to recover and secure their first 4-0 start since 2020. Mahomes connected notably with Travis Kelce, who set the franchise's career receptions record, while Samaje Perine's touchdown run in the fourth quarter clinched the victory. The game was marred by an injury to wide receiver Rashee Rice, who was carted off with a possible torn ACL after a collision following a Mahomes interception. Quarterback Justin Herbert, despite struggling with a high ankle sprain, completed 16 of 27 passes but faced considerable pressure from the Chiefs' defense. The Chargers fell to 2-2, continuing their struggles against Kansas City, who have now won six straight against them.