San Francisco Central Drug Store Plans Closure After 117 Years

Central Drug Store, a historic family-owned pharmacy in San Francisco's Excelsior District, will close permanently on July 15, 2025, as owner Jerry Tonelli retires after nearly 50 years of service. The pharmacy, established in 1908 and operated by the Tonelli family since 1965, has outlasted major chains such as Walgreens, CVS, and Rite Aid, as well as mail order services, making it the oldest retail establishment in the district. Tonelli emphasized that the closure is his choice and that no family members will be taking over the business, marking the end of a 117-year chapter. Despite industry-wide challenges and the rise of pharmacy deserts due to widespread shutdowns and closures by competitors, Central Drug Store maintained a strong community presence, serving customers including those without health insurance. The store’s walls are adorned with photos and mementos reflecting generations of loyal patrons. Tonelli expressed gratitude to customers and highlighted the importance of moving on to the next phase of life to spend more time with family.