The Baltimore Orioles eliminated the San Francisco Giants from playoff contention with a dramatic 5-3 victory, punctuated by Anthony Santander's walk-off two-run homer in the bottom of the ninth inning. Santander's 42nd home run of the season came after Casey Schmitt had tied the game for the Giants in the top half of the inning. Despite Michael Conforto's early two-run homer, the Giants fell short as they continued their struggles in September, dropping to 6-9 for the month. The Orioles, who had lost eight of their last ten games, moved closer to securing a wild card spot in the AL playoffs. The game also featured notable plays like Adley Rutschman's RBI double and Jackson Holliday's two-run single. Orioles’ closer Seranthony Domínguez faced difficulties in the ninth but was relieved by Gregory Soto who maintained the tie before Santander's game-winning hit.