A recent study from McLean Hospital indicates that high doses of Adderall and other amphetamines significantly increase the risk of psychosis and mania, with a fivefold rise noted for those taking 30 mg or more of dextroamphetamine. Researchers found that individuals with a prescription for these stimulants were over 60% more likely to experience these mental health issues compared to non-users, and 81% of psychosis cases could potentially be avoided with lower dosages. Lead author Dr. Lauren Moran emphasized the importance of dose management when prescribing stimulants, as there is no upper limit specified on their labels. While the overall risk remains low, families of patients on high doses should be vigilant for symptoms of psychosis, such as hallucinations or delusions. The study analyzed emergency admissions over nearly 15 years, identifying a clear link between higher stimulant dosages and adverse psychiatric effects. These findings have raised concerns about the increasingly prevalent prescribing practices for ADHD medications, particularly during the COVID-19 pandemic.