49ers Rely on Rookies Amid Injuries, Roster Battles

The San Francisco 49ers are navigating a transitional 2025 preseason marked by key injuries and significant position battles. Offensive linemen Nick Zakelj and Spencer Burford are competing for starting roles as Ben Bartch recovers from injury, with Andre Dillard also in the mix. The defense is undergoing a rebuild, with rookies Mykel Williams, Alfred Collins, and CJ West expected to play major roles after several veteran departures. Defensive lineman Kevin Givens will miss the start of the regular season with a pectoral injury, prompting a competition between rookies Collins and West for his position. Running back Isaac Guerendo is sidelined for several weeks due to a shoulder injury, giving rookie Jordan James increased preseason opportunities. These developments highlight the 49ers' reliance on young talent and the impact of preseason performances on their 2025 roster.