Seattle Seahawks wide receiver DK Metcalf will miss the game against the Buffalo Bills due to a sprained medial collateral ligament in his knee, sustained during a game against the Atlanta Falcons. This marks only the second game Metcalf has missed in his six-year NFL career, and his absence leaves quarterback Geno Smith to rely on Tyler Lockett, Jaxon Smith-Njigba, and Jake Bobo. The Seahawks hope Metcalf can return for their next game against the Los Angeles Rams. Meanwhile, the Buffalo Bills will see practice squad players Eli Ankou and Jalen Virgil make their season debuts due to injuries among their lineup. Seattle's defense will also be affected, with Cameron Young and Mike Morris inactive, although Tre Brown and Riq Woolen will be returning from injuries to strengthen the secondary.