The San Francisco 49ers' offense is facing significant challenges following a 23-17 loss to the Minnesota Vikings, as star wide receiver Deebo Samuel has been sidelined for a couple of weeks due to a calf strain sustained during the game. This injury follows the placement of All-Pro running back Christian McCaffrey on injured reserve due to calf tightness and Achilles tendinitis, leaving the team without two of its top offensive players. Samuel, who has been the leading receiver for the 49ers this season with 13 catches for 164 yards, also played a crucial role as a dual-threat option in the backfield. Head coach Kyle Shanahan acknowledged the difficulties posed by these injuries, highlighting the need for the team to adapt strategically. The 49ers will face the Los Angeles Rams next, hoping to recover key players before a critical matchup against the Kansas City Chiefs in Week 7. The situation puts additional pressure on quarterback Brock Purdy and the remaining roster to maintain offensive production.