Recent data from WastewaterSCAN and various monitoring networks indicate a rise in Enterovirus D68 (EV-D68) across the United States, with medium levels detected in numerous samples, particularly in the South and Northeast. EV-D68, which typically causes mild respiratory symptoms, has been linked to a serious neurological condition, acute flaccid myelitis (AFM), that can result in severe paralysis in children. Since the CDC began tracking AFM in 2014, there have been periodic surges, with notable outbreaks recorded every two years until COVID-19 lockdowns in 2020 interrupted this pattern. This year, 13 cases of AFM have been confirmed, raising concerns among health experts about a potential increase in cases as EV-D68 levels continue to rise. The condition remains largely mysterious, with no specific treatment or cure, and ongoing research is essential to understand its behavior and develop potential therapies.