Defending champions Coco Gauff and Novak Djokovic are set to compete on Day 5 of the US Open 2024, with Gauff facing Elina Svitolina in the second round and Djokovic taking on Alexei Popyrin in the third round. Djokovic is pursuing a record 25th Grand Slam singles title, having previously defeated Popyrin in their two prior Grand Slam encounters this year. Gauff, who won her last match against Tatjana Maria, is on a nine-match winning streak at the tournament. Aryna Sabalenka, last year's finalist, will also play against Ekaterina Alexandrova, while Rohan Bopanna will compete in men's doubles and mixed doubles matches. The event highlights the ongoing challenges for former champions, as notable players like Ashleigh Barty and Victoria Azarenka have never won the US Open despite reaching world No. 1 status. Additionally, the article reflects on past defending champions who faced early exits in their title defenses.