In a thrilling season opener, No. 23 USC defeated No. 13 LSU 27-20 in Las Vegas, marking the Trojans' first win as members of the Big Ten conference. Quarterback Miller Moss led USC with a game-winning drive that culminated in a touchdown run by Woody Marks with just eight seconds left. LSU's Garrett Nussmeier had a strong performance, throwing for 304 yards and two touchdowns, but his late interception sealed the game for USC. The match featured standout plays, including a remarkable one-handed catch by USC's Kyron Hudson, and LSU's defense showed flashes of improvement under new coordinator Blake Baker, despite allowing several big plays. The game ended with both teams tied at halftime and showcased the offensive capabilities of both squads, but USC's late-game execution made the difference. This loss marks LSU's fifth consecutive season opening defeat.