African nations have reported a disturbing rise in mpox-related deaths, with 107 fatalities and 3,160 new cases recorded in just one week, prompting the Africa CDC to label the situation as 'not acceptable.' Dr. Jean Kaseya, the director-general, emphasized the urgent need for enhanced cross-border surveillance and increased testing resources, noting that men have the highest positivity rate at 63%. The World Health Organization declared the outbreaks a global emergency last month, leading to a $600 million continental response plan aimed at addressing the crisis in 14 affected countries. While Congo has received 250,000 vaccine doses, significantly more are needed to combat the outbreak, with EU countries pledging over 500,000 doses. Kaseya called for further research into mother-to-child transmission of mpox, underscoring the need for comprehensive data to inform decision-making. The ongoing situation highlights the critical challenges faced by healthcare systems in Africa as they struggle to manage the escalating outbreak.