49ers Shorthanded: Purdy, Pearsall, Jennings Out

The San Francisco 49ers have ruled out QB Brock Purdy (recurring toe) — his toe flared after returning in Week 4 and he had missed Weeks 2–3 with the same injury. WRs Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs), along with Jordan Watkins and DE Robert Beal, are also out, with Pearsall still leading the team with 327 receiving yards. Backup Mac Jones will start his third game; he was a full participant this week, will wear a knee brace, and has 563 yards, four TDs and one INT across his two starts. Adrian Martinez is set as the team's backup. With Brandon Aiyuk and George Kittle already sidelined, San Francisco is expected to lean on Demarcus Robinson and Kendrick Bourne as primary targets while Skyy Moore, Marquez Valdes-Scantling and potential practice‑squad elevations (Russell Gage, Malik Turner or Junior Bergen) provide depth. Both teams enter the game 3-1, and the multiple absences leave the 49ers shorthanded for a key NFC West matchup at the Los Angeles Rams.