Africa's top public health agency, the Africa Centres for Disease Control and Prevention (Africa CDC), has announced that mpox vaccinations will begin within days in the Democratic Republic of Congo (DRC) and other affected African countries. This initiative follows the World Health Organization's declaration of mpox as a global health emergency. The vaccination drive is being coordinated with international partners, including the EU, US, and Japan, to manage logistics and ensure safe vaccine administration. Meanwhile, Argentina and other Latin American countries have strengthened border health measures in response to the outbreak. The current mpox strain in Africa, clade 1b, is more virulent with higher mortality rates, and a case has been reported outside Africa in Sweden. The Africa CDC warns against travel bans, urging for global cooperation to combat the outbreak effectively.