The highly anticipated 21st season of 'Grey's Anatomy' premieres on September 26, 2024, featuring dramatic tensions as Meredith Grey returns to Grey Sloan Memorial amidst a conflict with Catherine Fox. The teaser reveals familiar faces like Kali Rocha and Jesse Williams, while showcasing confrontations, including a slap between characters Miranda Bailey and Catherine. The season will explore unique medical cases stemming from a climate change protest and the departure of key characters, including Levi Schmitt and Mika Yasuda. Meredith's struggle over her Alzheimer's research continues to create friction, particularly with Catherine's interference. Viewers can expect riveting storylines and memorable moments as old and new characters navigate the complexities of life and medicine.