The Green Bay Packers defeated the Indianapolis Colts 16-10, improving to 1-1 while the Colts fell to 0-2. Malik Willis, filling in for injured quarterback Jordan Love, threw his first career touchdown and helped the Packers dominate the ground game, with Josh Jacobs rushing for 151 yards. Despite a late touchdown pass from Anthony Richardson to Antonio Pierce, the Colts struggled offensively, with Richardson throwing three interceptions and failing to capitalize on scoring opportunities. Green Bay's defense held strong, recovering an onside kick and intercepting a Hail Mary attempt to seal the victory. The Colts' disappointing performance raised concerns about their run defense and the effectiveness of their offense moving forward, especially without key players. The game highlighted the Colts' ongoing struggles and the Packers' ability to adapt their game plan under pressure.