Exercise is a crucial element in maintaining overall health, and its benefits include enhancing cardiovascular health, physical fitness, and mental clarity. It is essential to consider individual responses to exercise and tailor doses to maximize benefits. Precision medicine aims to customize treatment and prevention strategies to individuals' characteristics, including their genetics, environment, and lifestyle. The timing of exercise can also influence its benefits, with studies suggesting that exercising in the afternoon may be more beneficial for certain health conditions. While taking scheduled rest days is crucial to avoid injuries and promote muscle repair and strength development.