The Minnesota Vikings are facing injury concerns ahead of their game against the San Francisco 49ers, with safety Harrison Smith and tackle Brian O'Neill appearing on the injury report. Smith did not participate in practice due to a hip injury, while O'Neill was limited with an elbow issue, critical as he prepares to face the 49ers' Nick Bosa. Additionally, wide receiver Jordan Addison is likely to miss the game due to an ankle injury sustained in Week 1, shifting the focus to Jalen Nailor and others to step up. For the 49ers, star running back Christian McCaffrey is currently limited in practice due to Achilles tendinitis and a calf strain, but he remains optimistic about playing. The outcome of these injuries could significantly impact both teams' performance in this highly anticipated matchup. Updates on the status of all players are expected as the week progresses.