49ers Place WR Brandon Aiyuk on PUP List, Out Weeks

The San Francisco 49ers have placed wide receiver Brandon Aiyuk on the reserve physically-unable-to-perform (PUP) list, sidelining him for at least the first four games of the 2025 season as he continues to recover from ACL and MCL tears sustained in Week 7 of last season. Head coach Kyle Shanahan has indicated that Aiyuk could return around Week 6, possibly for a game against the Tampa Bay Buccaneers, although this timeline remains tentative. The team is also without top receivers Deebo Samuel, who was traded, and Jauan Jennings, who is dealing with a calf injury and contract issues, leaving Ricky Pearsall and others to carry the receiving load early in the season. Other wide receivers like Terique Owens, Isaiah Hodgins, and Robbie Chosen were released during final roster cuts, with the team having recently acquired Skyy Moore in a trade to bolster the position. The 49ers' receiver situation remains challenging as they navigate injuries and roster changes heading into the new season. This strategic move aligns with the team's cautious approach to Aiyuk's recovery and the need to manage the wide receiver corps carefully amid multiple absences.