In a thrilling season opener, No. 23 USC defeated No. 13 LSU 27-20 in Las Vegas, marking a significant statement as the Trojans enter their first season in the Big Ten Conference. Redshirt junior quarterback Miller Moss led USC with 378 passing yards and a touchdown, while running back Woody Marks secured the victory with a game-winning 13-yard touchdown run with just eight seconds left. The Trojans, showcasing a revamped roster and coaching staff, demonstrated resilience after LSU tied the game at 20-20 with 1:47 remaining. Key plays included a crucial 20-yard reception by Kyron Hudson, who also received a targeting penalty against LSU that set up Marks' decisive score. This victory ended LSU's four-game winning streak and marked their third consecutive season-opening loss under coach Brian Kelly. As both teams aim for College Football Playoff spots, USC's performance signals their potential as a formidable contender this season.