Padres' Manny Machado Hits 350th Career Home Run Amid 3-2 Loss to Giants

San Diego Padres star Manny Machado hit the 350th home run of his career during a close 3-2 loss to the San Francisco Giants at Oracle Park. Machado's two-run homer in the third inning gave the Padres an early lead, but the Giants rallied with three runs in the same inning to secure the win. Machado, who is batting .316 in 2025, has joined an elite group of players with 350 home runs before turning 33 and is on pace for the best batting average of his career. He is also one of only 10 third basemen in MLB history to reach 350 homers, joining legends like Mike Schmidt and Adrian Beltre. Despite the milestone, the Padres fell short in the ninth inning, unable to overcome closer Camilo Doval. Machado’s performance this season, including his recent power surge, highlights his trajectory toward Cooperstown and cements his status as a franchise icon.