Brandon Aiyuk of the 49ers suffered a season-ending knee injury, complicating the team's wide receiver situation, but in-house replacements like Jauan Jennings and Ricky Pearsall could fill the void for fantasy managers. Meanwhile, Indiana's star quarterback Kurtis Rourke is expected to miss the upcoming game against Washington due to a thumb injury, although backup Tayven Jackson is prepared to step in. The college football landscape is experiencing significant upheaval with Texas, Alabama, and other playoff contenders facing unexpected losses and injuries as the season progresses. Notably, several key players, including Notre Dame's Benjamin Morrison and Tennessee's Keenan Pili, are out for the season, raising concerns for their respective teams. Florida State is also navigating an injury crisis as they prepare to face Duke, relying on a youthful roster. As the season reaches its midway point, the chaos and unpredictability of college football remain evident.