Antimicrobial resistance (AMR) has emerged as a significant global health threat, now the fifth leading cause of death worldwide, as highlighted by PharmTech Richard Ofosu Addai during the PTAG Annual General Conference in Ghana. He emphasized the need for collaboration across sectors to tackle AMR, linking it to pollution from illegal mining activities, which exacerbates the crisis through heavy metal contamination. In India, experts revealed that seven out of ten critical care patients exhibit antibiotic resistance, stressing the dangers of antibiotic misuse and the need for better public awareness regarding proper antibiotic use. Concurrently, the World Health Organization has released groundbreaking guidance addressing antibiotic pollution from manufacturing, warning that unregulated antibiotic discharge into waterways contributes to the spread of resistant bacteria. Furthermore, a recent study indicates that air pollution may indirectly lead to increased antibiotic prescriptions due to misdiagnosis of respiratory symptoms, thereby aggravating AMR. Overall, these findings underline the urgent need for comprehensive strategies to combat AMR through environmental regulation, education, and responsible antibiotic usage.