San Francisco 49ers star tight end George Kittle missed practice on Thursday due to hamstring tightness, putting his availability for Sunday's Week 3 matchup against the Los Angeles Rams in doubt. This injury adds to the 49ers' offensive woes, as running back Christian McCaffrey is on injured reserve with calf and Achilles issues, and wide receiver Deebo Samuel is out with a calf strain. Kittle, who has recorded 11 receptions for 116 yards and one touchdown this season, played 51 of 70 offensive snaps in Week 2 against the Vikings but was hindered by cramping. The 49ers, currently 1-1, face significant challenges as they prepare to play the Rams without key players. Kittle's absence would further deplete an already injury-ridden team, potentially pushing Eric Saubert into a starting role. The Rams are also dealing with their own injury issues, particularly on the offensive line and at the receiver position.