The Eastern Band of Cherokee Indians (EBCI) successfully launched recreational marijuana sales on September 7, 2024, making it the first indigenous tribe to establish a regulated cannabis marketplace in the U.S. before state legalization. The Great Smoky Cannabis Co. in Cherokee attracted over 4,000 customers on its opening weekend, with long lines forming as early as 1 a.m. for the historic event. This initiative follows a 2023 referendum where 70% of tribal members supported adult-use cannabis, asserting the tribe's sovereignty over cannabis regulation. The dispensary had over 350 products available, and sales of infused edibles exceeded expectations, with plans to expand to 500 items by January. Despite opposition from some North Carolina officials, the tribe anticipates gross sales revenues of nearly $385 million in the first year. The opening is seen as a significant milestone for the tribe, marking a new chapter of economic opportunity and community growth.