A new study published in JAMA Pediatrics found that newborns with atypical metabolic patterns are significantly more likely to die from sudden infant death syndrome (SIDS). The research, funded by the NIH and conducted by UC San Francisco, analyzed data from newborn screenings in California, comparing infants who died of SIDS with those who survived. Infants with specific metabolic biomarkers, such as lower levels of C-3 and elevated levels of C-14OH, were found to be up to 14 times more likely to die from SIDS. The findings suggest that early screening for these metabolic patterns could help identify at-risk infants and inform preventive measures. Researchers emphasize the need for further investigation to understand the biochemical pathways involved and to develop potential treatments or preventive strategies. SIDS remains a leading cause of unexplained infant deaths in the U.S., with around 1,300 annual fatalities, highlighting the urgent need for effective preventive measures.