The Baltimore Orioles suffered a significant 12-3 defeat against the Boston Red Sox, marking their worst loss of the second half of the season and leaving them 1½ games behind the New York Yankees in the AL East. Anthony Santander stood out for the Orioles, driving in all three of their runs, including his milestone 40th home run of the season, making him the third player this year to reach that mark. Despite Santander's performance, the Orioles struggled offensively, leaving 11 runners on base and having difficulty against the Red Sox bullpen. Rob Refsnyder and Tyler O'Neill powered the Red Sox offense, each hitting two home runs and combining for seven RBIs. Cade Povich, starting for the Orioles, allowed four runs over 4 2/3 innings, with the team’s pitching faltering later in the game. Orioles manager Brandon Hyde acknowledged the team's missed opportunities and emphasized the need to move forward after the defeat.