In a thrilling shootout, No. 6 Miami defeated Louisville 52-45, with Hurricanes quarterback Cam Ward throwing for four touchdowns and leading a potent offense that amassed 538 total yards. Despite Louisville's strong offensive performance, scoring 38 points, their defense struggled significantly, allowing Miami to convert on 9 of 15 third downs and yielding numerous big plays. Louisville coach Jeff Brohm acknowledged the need for improvement, particularly in tackling and defensive consistency, as the Cardinals continue to face tough competition ahead. The game featured several lead changes, with Miami's late touchdowns sealing the victory and maintaining their unbeaten record. After the loss, the Cardinals' hopes for a conference championship diminished, raising questions about the future of their defensive coaching staff. The match-up not only showcased Miami's offensive prowess but also highlighted the ongoing issues plaguing Louisville's defense.