San Francisco 49ers right guard Spencer Burford is expected to miss three to four weeks due to a broken right hand, with team coach Kyle Shanahan indicating that surgery is still under consideration. Burford, who has started 29 games since joining the NFL, was taking first-team reps before the injury occurred. His absence opens the door for rookie Dominick Puni to gain significant playing time, as veteran Jon Feliciano is also sidelined with a knee injury. Meanwhile, other injury updates include rookie receiver Ricky Pearsall, who may return to practice soon, and safety Talanoa Hufanga, who is recovering from an ACL injury. The 49ers' offensive line continues to face challenges with multiple injuries as they prepare for the upcoming season.