The Los Angeles Rams suffered a humiliating 41-10 defeat to the Arizona Cardinals, marking their first 0-2 start under coach Sean McVay. Kyler Murray dominated the game, throwing for 266 yards and three touchdowns, including two to rookie Marvin Harrison Jr., who made a notable debut with 130 receiving yards. The Rams, plagued by injuries, particularly to their offensive line and star receiver Cooper Kupp, managed only 53 rushing yards and allowed five sacks on quarterback Matthew Stafford. This loss ended a nine-game winning streak for the Rams in Arizona, as they struggled to establish any offensive rhythm. Coach McVay remarked on the humbling experience, highlighting the team's need for resilience moving forward, especially with the defending NFC champion San Francisco 49ers next on their schedule.