49ers Win Narrowly, Face Key Injuries to Bosa, Green in NFC West Clash

The San Francisco 49ers continue to grapple with significant injury challenges, particularly on defense, during their 2025 NFL season. In their Week 3 game against the Arizona Cardinals, star defensive end Nick Bosa exited early with a knee injury and was ruled out, dealing a major blow to the team's pass rush. Rookie defensive end Mykel Williams also sustained a wrist injury in the same game, leaving the 49ers with limited healthy edge rushers. Cornerback Renardo Green briefly left the game due to injury but returned later, which provided some relief in the secondary. These defensive setbacks compound the 49ers' ongoing offensive injury issues, including absences of key players like quarterback Brock Purdy, tight end George Kittle, and wide receiver Jauan Jennings. Despite these challenges, the 49ers managed a narrow 16-15 victory over the Cardinals, but their depth and injury situation remain pressing concerns.