The Indianapolis Colts secured a 21-13 victory over the Arizona Cardinals in their second preseason game, showcasing strong performances from backup players. Colts running back Zavier Scott stood out with 11 carries for 55 yards and a touchdown, while quarterback Jason Bean threw for 94 yards and added a rushing touchdown. The Cardinals struggled offensively, accumulating only 232 yards and committing 11 penalties, with quarterback Clayton Tune showing promise despite being sacked three times. Defensively, the Colts dominated, with rookie pass rusher Adetomiwa Adebawore earning a high pass rush grade and consistently pressuring the Cardinals' offensive line. The game marked the first preseason meeting between the franchises since 1967, but key players like Cardinals rookie Marvin Harrison Jr. did not participate. The Cardinals now face questions about their offensive cohesion and competition for the backup quarterback position as the regular season approaches.