Pacheco Ruled Out; Chiefs Also Lose Simmons

The Buffalo Bills will host the Kansas City Chiefs on Sunday in a high-stakes AFC showdown, and the Chiefs will be without starting RB Isiah Pacheco — ruled out with a sprained MCL after missing practice all week — and starting left tackle Josh Simmons (personal reasons). Kansas City plans to lean on Kareem Hunt as the primary ball-carrier, with rookie Brashard Smith and veteran Elijah Mitchell expected to see rotational snaps, a change that could alter play‑calling and short‑yardage usage. Right guard Trey Smith (back) and backup left tackle Jaylon Moore (illness) are listed as questionable, leaving the offensive line situation fluid for the road test in Buffalo. The team has a Week 10 bye and hopes both Pacheco and Simmons can return by Nov. 16 against Denver. How the Chiefs manage their depleted backfield and line will be one of the decisive storylines in the matchup.