The San Francisco 49ers suffered a 24-23 defeat against the Arizona Cardinals, marking their second blown double-digit lead in the fourth quarter this season. Despite leading 23-10 at halftime, the 49ers failed to score in the second half, committing three turnovers on four second-half possessions. Contributing to the loss were inefficiencies in the red zone, as they only managed one touchdown from six red zone trips. The Cardinals' comeback was propelled by Kyler Murray's dynamic performance, including a critical 35-yard field goal by Chad Ryland with 1:37 left in the game. This loss leaves the 49ers at 2-3 for the season, creating significant challenges for their NFC West ambitions. The 49ers' struggles are attributed to questionable playcalling and execution, especially in red zone situations.